Sertraline, Obesity, and Longevity: Revealing the Association | Prime MD Plus. See our doctor in the DFW area

Sertraline, Obesity, and Longevity: Revealing the Association

Dr. Divya Javvaji, MD
Prime MD Plus

Have you ever wondered if the medication you take for your mental health could affect your weight and overall lifespan? In this article, we explore the fascinating link between sertraline, obesity, and longevity. As a medical professional, I am here to shed light on this complex relationship and provide you with evidence-based insights.

While sertraline, commonly known as an antidepressant, is primarily prescribed to alleviate symptoms of depression and anxiety, recent studies have suggested a potential connection between its use and weight gain. Join me as we delve into the science behind this phenomenon and uncover the implications it may have on your health.

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Does Sertraline Cause Obesity?

Does sertraline cause obesity? This question has intrigued researchers and patients alike. While it is not accurate to claim that sertraline directly causes obesity, studies have shown that it can contribute to weight gain. Sertraline belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs), which work by increasing the levels of serotonin in the brain. Serotonin plays a role in regulating appetite and satiety, and alterations in its levels can potentially lead to changes in weight.

Furthermore, sertraline may affect metabolism, making it easier for individuals to gain weight and harder to lose it. The medication can potentially slow down the body’s metabolic rate, leading to the accumulation of excess pounds over time. However, it’s important to note that not everyone who takes sertraline will experience weight gain, and the extent of weight gain varies among individuals.

How Sertraline Can Affect Your Health and Longevity?

While the impact of sertraline on weight gain is a topic of concern, it is essential to understand how it may affect your overall health and longevity. Here are some key points to consider:

  1. Metabolic effects: Sertraline can potentially increase the risk of developing conditions such as diabetes and metabolic syndrome, which may have a negative impact on your lifespan.
  2. Lifestyle factors: Weight gain associated with sertraline use can lead to a sedentary lifestyle and unhealthy eating habits, both of which can contribute to obesity-related health issues and a reduced lifespan.
  3. Mental health: Sertraline’s primary purpose is to improve mental well-being. By effectively managing depression and anxiety, it can indirectly promote a healthier lifestyle and positively influence longevity.

It’s crucial to remember that every individual’s response to sertraline and its impact on weight and longevity can vary. Consult with your healthcare provider for personalized advice and guidance regarding your specific situation.

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Data Source

The data presented on lifespan trends comes from, a highly reputable platform that provides comprehensive demographic data on mortality rates worldwide. It’s a collaborative project of respected research institutions such as the Department of Demography at the University of California, Berkeley; the Max Planck Institute for Demographic Research; and INED – French Institute for Demographic Studies.’s datasets are trusted globally by researchers and policy makers due to their rigorous research methods and commitment to privacy and ethical guidelines. As such, readers can be confident that our report offers precise insights into the lifespan trends backed by authoritative research.

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